To send email using python script via Office 365, use below code. This code is tried and tested.

import smtplib, os
from email.mime.multipart import MIMEMultipart
from email.mime.text import MIMEText



def send_email():
    try:    
        # Create message container - the correct MIME type is multipart/alternative.
        msg = MIMEMultipart('alternative')
        
        msg['From'] = "fromemail@domain.com"
        msg['To'] = "toemail@domain.com"        
        msg['Subject'] = "test subject"
        
        # see the code below to use template as body
        body_text = "Hi this is body text of email"
        body_html = "<p>Hi this is body text of email</p>
        
        # Create the body of the message (a plain-text and an HTML version).
        # Record the MIME types of both parts - text/plain and text/html.
        part1 = MIMEText(body_text, 'plain')
        part2 = MIMEText(body_html, 'html')

        # Attach parts into message container.
        # According to RFC 2046, the last part of a multipart message, in this case
        # the HTML message, is best and preferred.
        msg.attach(part1)
        msg.attach(part2)
        
        # Send the message via local SMTP server.
        
        mail = smtplib.SMTP("smtp.outlook.office365.com", 587, timeout=20)

        # if tls = True                
        mail.starttls()        

        recepient = [toemail@domain.com]
                    
        mail.login(<login>, <password>)        
        mail.sendmail("fromemail@domain.com", recepient, msg.as_string())        
        mail.quit()
        
    except Exception as e:
        raise e

The email contains two body part, HTML and text. You can use Django template in email.

from django.utils.html import strip_tags
from django.template import Context, Template
from django.template.loader import get_template


template = get_template("myapp/sample_template.html")
context = Context(context_data)
body_html = template.render(context_data)			
body_text = strip_tags(body_html)

It is always advisable to store credentials in a separate config file and not to commit that file on Github.

The same code can be used to send an email via Gmail and Google Apps with slight modification.

Use the below settings:

Gmail :

Host : smtp.gmail.com
Port : 587
tls : True

Google Apps:

Host : smtp.gmail.com
Port : 465
tls : False

Warning: Do not send too many emails using the python script via Gmail. Your account may be blocked. Daily email limit is 500 or 1000 emails. 

If you are sending more than 500 emails daily, I recommend using Mailgun. They provide nice API and you can send 20000 emails per month for free.

Read also: How to send bulk emails using Mailgun and Python-Django.